Table 2.

Overview of studies evaluating cognitive rehabilitation for POMS: Study design.

Author (Year)	Intervention (Duration and Frequency)	Supervision or Coaching	Targeted Cognitive Domain	Study Participants	Comparator Group	Outcome Measures
Hubacher et al. (2015) [22]	computerized training (BrainStim) for 4 weeks (45 min/session, 4 times/week)	supervised by a psychologist once per week	working memory (visuospatial and verbal)	5 juvenile MS patients (age 12–17 years; 3 females)	Absent	Cognitive measures: working memory (visuospatial and verbal) and attention (alertness)
Simone et al. (2018) [24]	computerized training for 3 months (1 h/session, twice/week)	a psychologist called patients every week and met patients and their caregiver/parent every month	attention	16 POMS patients (age 15.75 ± 1.74 years; 9 females)	Present (nonspecific training)	Neuropsychological performance (using elaborate test battery)
Till et al. (2019) [23]	web-based training (Cogmed™) for 5 weeks (<1 h/session, 5 d/week)	weekly telephone support by a trained Cogmed™ Coach	working memory (visuospatial and verbal)	9 POMS patients (age 19.3 ± 4.1 years; 6 females)	Absent	Feasibility measures: adherence and tolerance; Cognitive measures: working memory, processing speed, visuospatial judgment