Table 3.

Original studies evaluating cognitive rehabilitation for POMS: Summary of results.

Author (Year)	Intervention	Effects on Targeted or Related Cognitive Domains	Far Transfer Effect	Sustainability of Effect	Factors Associated with Training Response, and Additional Notes
Hubacher et al. (2015) [22]	computerized training (BrainStim) for 4 weeks (45 min/session, 4 times/week)	Two (of 5) were responders; both responders showed better WM (visuospatial and verbal), processing speed, and alertness.	Not assessed	Sustained behavioral response at 9 months in both responders	Disease activity and general intelligence may be factors associated with training response.
Simone et al. (2018) [24]	computerized training for 3 months (1 h/session, twice/week)	Improved attention, processing speed, and WM.	Improved executive function and visuospatial memory	NA	Not reported
Till et al. (2019) [23]	web-based training (Cogmed™) for 5 weeks (<1 h/session, 5 d/week)	Subjective: 8 (out of 9) reported improvement in WM; Objective: medium to large effect size on neuropsychological measures of WM.	Limited	NA	Indicators of feasibility: 6/9 adherence; 8/9 tolerance. The participant who showed the least improvement had the youngest age at disease onset, longest disease duration, highest number of relapses, and lowest normalized brain volume. The participant who did not tolerate the training had the lowest IQ.

Abbreviations: NA, not available; WM: working memory.