Figure 3.

Plasma homocysteine (Hcy) levels or folate levels and the degree of hippocampal atrophy were not significantly correlated. There were no significant correlations between baseline Hcy levels and baseline hippocampal atrophy as estimated by the z-score produced by the voxel-based specific regional analysis system developed for the study of Alzheimer’s disease (VSRAD) (p = 0.521, Rs = 0.124). (A) The folate concentration and hippocampal atrophy based on the VSRAD z-score were not significantly correlated (p = 0.069, R = 0.343). (B) Spearman’s rank correlation coefficient was used for analysis because the data deviated from a normal distribution.