Table 1.
G protein-coupled receptors involved in metabolic function of hepatocytes.
| Gene Symbol (Human) | Receptor Name | Family | Transduction Mechanisms | |||
|---|---|---|---|---|---|---|
| GCGR | Glucagon receptor (GCGR) | Glucagon receptors | Gs | |||
| TRHR | Thyrotropin-releasing hormone receptor (TRH) | Thyrotropin-releasing hormone receptors | Gs | Gq | ||
| ADRB1 | β1-adrenoceptor (B1AR) | Adrenoceptors | Gs | Gi | ||
| ADRB2 | β2-adrenoceptor (B2AR) | Adrenoceptors | Gs | Gi | ||
| PTGER4 | Prostaglandin E receptor 4 (EP4) | Prostanoid receptors | Gs | Gi | Gq | |
| S1PR2 | Sphingosine-1-phosphate receptor 2 (S1PR2) | Lysophospholipid (S1P) receptors | Gs | Gq | G12/13 | |
| CNR1 | Cannabinoid receptor 1 (CB1) | Cannabinoid receptors | Gi | Gs | ||
| ADORA1 | Adenosine A1 receptor (A1) | Adenosine receptors | Gi | Gq | Gs | G12/13 |
| ADORA3 | Adenosine A3 receptor (A3) | Adenosine receptors | Gi | G12/13 | ||
| HCAR2 | Hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) | Hydroxycarboxylic acid receptors | Gi | |||
| CCR2 | C-C chemokine receptor type 2 (CCR2) | Chemokine receptors | Gi | |||
| CCR5 | C-C chemokine receptor type 5 (CCR5) | Chemokine receptors | Gi | |||
| P2RY13 | Purinergic receptor P2Y13 (P2Y13) | P2Y receptors | Gi | |||
| SMO | Smoothened receptor (SMO) | Class Frizzled GPCRs | Gi | G12/13 | ||
| AVPR1A | Arginine vasopressin receptor 1A (AVPR1A) | Vasopressin and oxytocin receptors | Gq | |||
| OXTR | Oxytocin receptor (OT) | Vasopressin and oxytocin receptors | Gq | Gi | ||
| P2RY1 | Purinergic receptor P2Y1 (P2Y1) | P2Y receptors | Gq | Gi | ||
| P2RY2 | Purinergic receptor P2Y2 (P2Y2) | P2Y receptors | Gq | Gi | G12/13 | |
| P2RY4 | Purinergic receptor P2Y4 (P2Y3) | P2Y receptors | Gq | |||
| P2RY6 | Purinergic receptor P2Y6 (P2Y6) | P2Y receptors | Gq | G12/13 | ||
| AGTR1 | Angiotensin II receptor type 1 (AT1) | Angiotensin receptors | Gq | Gi | ||
| FFAR4 | Free fatty acid receptor 4 (FFA4, CPR120) | Free fatty acid receptors | Gq | |||
| FFAR1 | Free fatty acid receptor 1 (FFA1, GPR40) | Free fatty acid receptors | Gq | Gs | Gi | |
| PTGER1 | Prostaglandin E receptor 1 (EP1) | Prostanoid receptors | Gq | Gi | ||
| HTR2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-Hydroxytryptamine receptors | Gq | Gi | ||
| HTR2B | 6-hydroxytryptamine receptor 2B (5-HT2B) | 5-Hydroxytryptamine receptors | Gq | |||