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Possible cellular mechanisms that connect defective torsinA/LAP1 complexes at the nuclear envelope to NAFLD/NASH pathogenesis. TorsinA interacts and from a heterohexameric structure with LAP1 in the nuclear envelope or with LULL1 in the ER. Red arrows indicate the plausible cellular pathways that torsinA/LAP1 are involved in in hepatocytes. See text for detailed descriptions.
