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. 2020 Oct 15;9(10):3311. doi: 10.3390/jcm9103311

Table 4.

Results from the F1-LD-F1 model reporting time, treatment, and interaction effects. Abbreviations: Sp = speleotherapy, Ex = winter exercise, T0 = day 0, T1 = day 10, T2 = day 60, 6MWT = six-minute walk test.

Parameter F1-LD-F1 Model Relative Treatment Effects (RTE)
F p-Value Time Speleotheapy Winter Exercise
6MWT Distance (%) Speleo 0.60 Exercise 0.37
Treat 9.59 (1.00, ∞) 0.010 * T0 0.43 Sp. × T0 0.53 Ex. × T0 0.34
Time 5.04 (1.95, ∞) 0.019 * T1 0.53 Sp. × T1 0.68 Ex. × T1 0.39
Treat × Time 1.50 (1.95, ∞) 1.000 n.s T2 0.49 Sp. × T2 0.59 Ex. × T2 0.39
Peak respiratory Speleo 0.50 Exercise 0.50
frequency (L/min) Treat 0.00 (1.00, ∞) 1.000 n.s T0 0.50 Sp. × T0 0.46 Ex. × T0 0.54
Time 0.06 (1.83, ∞) 1.000 n.s T1 0.50 Sp. × T1 0.52 Ex. × T1 0.49
Treat × Time 1.42 (1.83, ∞) 0.449 n.s T2 0.49 Sp. × T2 0.51 Ex. × T2 0.47
Peak minute Speleo 0.60 Exercise 0.38
ventilation (L/min) Treat 8.51 (1.00, ∞) 0.018 * T0 0.44 Sp. × T0 0.53 Ex. × T0 0.35
Time 5.81 (1.80, ∞) 0.018 * T1 0.55 Sp. × T1 0.70 Ex. × T1 0.40
Treat × Time 2.21 (1.80, ∞) 0.579 n.s T2 0.47 Sp. × T2 0.56 Ex. × T2 0.38
BORG Dyspnea Speleo 0.48 Exercise 0.52
pre (score) Treat 0.35 (1.00, ∞) 0.725 n.s T0 0.54 Sp. × T0 0.51 Ex. × T0 0.57
Time 2.42 (1.66, ∞) 0.198 n.s T1 0.45 Sp. × T1 0.42 Ex. × T1 0.48
Treat × Time 0.28 (1.66, ∞) 0.841 n.s T2 0.52 Sp. × T2 0.51 Ex. × T2 0.52
BORG Dyspnea post Speleo 0.55 Exercise 0.44
(score) Treat 1.84 (1.00, ∞) 0.876 n.s T0 0.54 Sp. × T0 0.56 Ex. × T0 0.52
Time 2.66 (1.80, ∞) 0.229 n.s T1 0.46 Sp. × T1 0.50 Ex. × T1 0.43
Treat × Time 2.70 (1.80, ∞) 0.376 n.s T2 0.48 Sp. × T2 0.58 Ex. × T2 0.38
BORG Fatigue pre Speleo 0.52 Exercise 0.48
(score) Treat 0.31 (1.00, ∞) 1.000 n.s T0 0.60 Sp. × T0 0.62 Ex. × T0 0.57
Time 10.60 (1.89, ∞) <0.001 *** T1 0.41 Sp. × T1 0.40 Ex. × T1 0.43
Treat × Time 1.16 (1.89, ∞) 1.000 n.s T2 0.49 Sp. × T2 0.53 Ex. × T2 0.44
BORG Fatigue post Speleo 0.54 Exercise 0.45
(score) Treat 1.46 (1.00, ∞) 1.000 n.s T0 0.56 Sp. × T0 0.61 Ex. × T0 0.51
Time 6.81 (1.94, ∞) 0.006 ** T1 0.49 Sp. × T1 0.53 Ex. × T1 0.45
Treat × Time 0.08 (1.94, ∞) 1.000 n.s T2 0.44 Sp. x T2 0.49 Ex. × T2 0.39

*** < 0.001; ** < 0.01; * < 0.05; < 0.1; n.s. not significant.