Table 4.
Results from the F1-LD-F1 model reporting time, treatment, and interaction effects. Abbreviations: Sp = speleotherapy, Ex = winter exercise, T0 = day 0, T1 = day 10, T2 = day 60, 6MWT = six-minute walk test.
| Parameter | F1-LD-F1 Model | Relative Treatment Effects (RTE) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| F | p-Value | Time | Speleotheapy | Winter Exercise | ||||||
| 6MWT Distance (%) | Speleo | 0.60 | Exercise | 0.37 | ||||||
| Treat | 9.59 (1.00, ∞) | 0.010 | * | T0 | 0.43 | Sp. × T0 | 0.53 | Ex. × T0 | 0.34 | |
| Time | 5.04 (1.95, ∞) | 0.019 | * | T1 | 0.53 | Sp. × T1 | 0.68 | Ex. × T1 | 0.39 | |
| Treat × Time | 1.50 (1.95, ∞) | 1.000 | n.s | T2 | 0.49 | Sp. × T2 | 0.59 | Ex. × T2 | 0.39 | |
| Peak respiratory | Speleo | 0.50 | Exercise | 0.50 | ||||||
| frequency (L/min) | Treat | 0.00 (1.00, ∞) | 1.000 | n.s | T0 | 0.50 | Sp. × T0 | 0.46 | Ex. × T0 | 0.54 |
| Time | 0.06 (1.83, ∞) | 1.000 | n.s | T1 | 0.50 | Sp. × T1 | 0.52 | Ex. × T1 | 0.49 | |
| Treat × Time | 1.42 (1.83, ∞) | 0.449 | n.s | T2 | 0.49 | Sp. × T2 | 0.51 | Ex. × T2 | 0.47 | |
| Peak minute | Speleo | 0.60 | Exercise | 0.38 | ||||||
| ventilation (L/min) | Treat | 8.51 (1.00, ∞) | 0.018 | * | T0 | 0.44 | Sp. × T0 | 0.53 | Ex. × T0 | 0.35 |
| Time | 5.81 (1.80, ∞) | 0.018 | * | T1 | 0.55 | Sp. × T1 | 0.70 | Ex. × T1 | 0.40 | |
| Treat × Time | 2.21 (1.80, ∞) | 0.579 | n.s | T2 | 0.47 | Sp. × T2 | 0.56 | Ex. × T2 | 0.38 | |
| BORG Dyspnea | Speleo | 0.48 | Exercise | 0.52 | ||||||
| pre (score) | Treat | 0.35 (1.00, ∞) | 0.725 | n.s | T0 | 0.54 | Sp. × T0 | 0.51 | Ex. × T0 | 0.57 |
| Time | 2.42 (1.66, ∞) | 0.198 | n.s | T1 | 0.45 | Sp. × T1 | 0.42 | Ex. × T1 | 0.48 | |
| Treat × Time | 0.28 (1.66, ∞) | 0.841 | n.s | T2 | 0.52 | Sp. × T2 | 0.51 | Ex. × T2 | 0.52 | |
| BORG Dyspnea post | Speleo | 0.55 | Exercise | 0.44 | ||||||
| (score) | Treat | 1.84 (1.00, ∞) | 0.876 | n.s | T0 | 0.54 | Sp. × T0 | 0.56 | Ex. × T0 | 0.52 |
| Time | 2.66 (1.80, ∞) | 0.229 | n.s | T1 | 0.46 | Sp. × T1 | 0.50 | Ex. × T1 | 0.43 | |
| Treat × Time | 2.70 (1.80, ∞) | 0.376 | n.s | T2 | 0.48 | Sp. × T2 | 0.58 | Ex. × T2 | 0.38 | |
| BORG Fatigue pre | Speleo | 0.52 | Exercise | 0.48 | ||||||
| (score) | Treat | 0.31 (1.00, ∞) | 1.000 | n.s | T0 | 0.60 | Sp. × T0 | 0.62 | Ex. × T0 | 0.57 |
| Time | 10.60 (1.89, ∞) | <0.001 | *** | T1 | 0.41 | Sp. × T1 | 0.40 | Ex. × T1 | 0.43 | |
| Treat × Time | 1.16 (1.89, ∞) | 1.000 | n.s | T2 | 0.49 | Sp. × T2 | 0.53 | Ex. × T2 | 0.44 | |
| BORG Fatigue post | Speleo | 0.54 | Exercise | 0.45 | ||||||
| (score) | Treat | 1.46 (1.00, ∞) | 1.000 | n.s | T0 | 0.56 | Sp. × T0 | 0.61 | Ex. × T0 | 0.51 |
| Time | 6.81 (1.94, ∞) | 0.006 | ** | T1 | 0.49 | Sp. × T1 | 0.53 | Ex. × T1 | 0.45 | |
| Treat × Time | 0.08 (1.94, ∞) | 1.000 | n.s | T2 | 0.44 | Sp. x T2 | 0.49 | Ex. × T2 | 0.39 | |
*** < 0.001; ** < 0.01; * < 0.05; < 0.1; n.s. not significant.