Table 4.
Sensitivity and specificity of gene expression of five chemokines in the pulmonary toxicity of nanomaterials.
| Sensitivity | Specificity | False Positive | False Negative | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 3 days | CXCL5 | 0.95 | (19/20) | 1.00 | (20/20) | 0.00 | (0/20) | 0.05 | (1/20) |
| CCL2 | 0.50 | (10/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.50 | (10/20) | |
| CCL7 | 0.50 | (10/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.50 | (10/20) | |
| CXCL10 | 0.30 | (6/20) | 1.00 | (20/20) | 0.00 | (0/20) | 0.70 | (14/20) | |
| CXCL11 | 0.35 | (7/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.65 | (13/20) | |
| CXCL5 + CCL2 + CCL7 | 0.90 | (18/20) | 0.05 | (1/20) | 0.95 | (19/20) | 0.10 | (2/20) | |
| 1 week | CXCL5 | 0.95 | (19/20) | 1.00 | (20/20) | 0.00 | (0/20) | 0.05 | (1/20) |
| CCL2 | 1.00 | (20/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.00 | (0/20) | |
| CCL7 | 0.95 | (19/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.05 | (1/20) | |
| CXCL10 | 0.75 | (15/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.25 | (5/20) | |
| CXCL11 | 0.75 | (15/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.25 | (5/20) | |
| CXCL5 + CCL2 + CCL7 | 1.00 | (20/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.00 | (0/20) | |
| 1 month | CXCL5 | 0.95 | (19/20) | 1.00 | (20/20) | 0.00 | (0/20) | 0.05 | (1/20) |
| CCL2 | 1.00 | (20/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.00 | (0/20) | |
| CCL7 | 1.00 | (20/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.00 | (0/20) | |
| CXCL10 | 0.65 | (13/20) | 1.00 | (20/20) | 0.00 | (0/20) | 0.35 | (7/20) | |
| CXCL11 | 0.65 | (13/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.35 | (7/20) | |
| CXCL5 + CCL2 + CCL7 | 1.00 | (20/20) | 0.90 | (18/20) | 0.10 | (2/20) | 0.00 | (0/20) | |
| 3 months | CXCL5 | 1.00 | (20/20) | 0.95 | (19/20) | 0.05 | (1/20) | 0.00 | (0/20) |
| CCL2 | 0.95 | (19/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.50 | (1/20) | |
| CCL7 | 0.95 | (19/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.50 | (1/20) | |
| CXCL10 | 0.75 | (15/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.25 | (5/20) | |
| CXCL11 | 0.90 | (18/20) | 0.75 | (15/20) | 0.25 | (5/20) | 0.10 | (2/20) | |
| CXCL5 + CCL2 + CCL7 | 1.00 | (20/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.00 | (0/20) | |
| 6 months | CXCL5 | 0.95 | (19/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.05 | (1/20) |
| CCL2 | 0.85 | (17/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.15 | (3/20) | |
| CCL7 | 0.85 | (17/20) | 0.85 | (17/20) | 0.15 | (3/20) | 0.15 | (3/20) | |
| CXCL10 | 0.55 | (11/20) | 0.80 | (16/20) | 0.20 | (4/20) | 0.45 | (9/20) | |
| CXCL11 | 1.00 | (20/20) | 0.70 | (14/20) | 0.30 | (6/20) | 0.00 | (0/20) | |
| CXCL5 + CCL2 + CCL7 | 1.00 | (20/20) | 0.30 | (6/20) | 0.70 | (14/20) | 0.00 | (0/20) | |
Sensitivity = (the number of true positives/the number of true positives + the number of false negatives). Specificity = (the number of true negatives/the number of false positives + the number of true negatives). False positive = (the number of false positives/the number of false positives + the number of true negatives). False negatives = (the number of false negatives/the number of true positives + the number of false negatives).