TABLE 2.
Estimated mean difference between groups for each Braak ROI
| Region | Groups compared | Estimated mean differences and 95% CI | Estimated mean differences and 95% CI (age adjusted) |
|---|---|---|---|
| Braak 1 | DS‐PiB (+) vs Controls‐PiB (−) | 0.23 (0.13, 0.32) | 0.19 (0.10, 0.30) |
| DS‐PiB (−) vs Controls‐PiB (−) | −0.01(−0.10, 0.08) | 0.01 (−0.08, 0.11) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.24 (0.18, 0.30) | 0.18 (0.11, 0.26) | |
| Braak 2 | DS‐PiB (+) vs Controls‐PiB (−) | 0.25 (0.15, 0.34) | 0.20 (0.10, 0.29) |
| DS‐PiB (−) vs Controls‐PiB (−) | 0.02 (−0.07, 0.11) | 0.06 (−0.03, 0.15) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.22 (0.16, 0.29) | 0.14 (0.06, 0.22) | |
| Braak 3 | DS‐PiB (+) vs Controls‐PiB (−) | 0.20 (0.08, 0.32) | 0.15 (0.03, 0.27) |
| DS‐PiB (−) vs Controls‐PiB (−) | −0.006 (−0.12, 0.11) | 0.03 (−0.08, 0.15) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.21 (0.13, 0.29) | 0.12 (0.02, 0.22) | |
| Braak 4 | DS‐PiB (+) vs Controls‐PiB (−) | 0.17 (0.07,0.27) | 0.12 (0.02, 0.22) |
| DS‐PiB (−) vs Controls‐PiB (−) | −0.002 (−0.10,0.09) | 0.04 (−0.06, 0.13) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.17 (0.11, 0.24) | 0.08 (0.003, 0.16) | |
| Braak 5 | DS‐PiB (+) vs Controls‐PiB (−) | 0.18 (0.06, 0.30) | 0.14 (0.02,0.27) |
| DS‐PiB (−) vs Controls‐PiB (−) | −0.002 (−0.12,0.12) | 0.03 (−0.09, 0.15) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.19 (0.12, 0.26) | 0.12 (0.02, 0.22) | |
| Braak 6 | DS‐PiB (+) vs Controls‐PiB (−) | 0.10 (−0.006, 0.20) | 0.08 (−0.02, 0.19) |
| DS‐PiB (−) vs Controls‐PiB (−) | −0.002 (−0.10,0.10) | 0.006 (−0.10, 0.11) | |
| DS‐PiB (+) vs DS‐PiB (−) | 0.10 (0.03, 0.17) | 0.08 (−0.007, 0.17) |
Note : Second column shows the estimated mean differences in AV‐1451 SUVR between groups adjusted for site, and third column shows the differences adjusted for site and age at scan.