Table 5.

Analysis of kinetic model parameters values for MTR and CUR released from minitablet.

	MTR				CUR
Parameters	k	n or m	r2	c2	k	n or m	r2	c2
$F=k_0\times t$ Zero-order	1.60 × 10−3		too low	6.78 × 10−2	2.42 × 10−4		0.798	4.15 × 10−4
$F=100\times \left(1-e^{-k_1\times t}\right)$ First-order a	1.60 × 10−5		too low	6.76 × 10−2	2.43 × 10−6		0.799	4.15 × 10−4
$F=F_{max}\times \left(1-e^{-k_1\times t}\right)$ First-order with Fmax b	2.30 × 10−2	Fmax = 0.261	0.994	2.01 × 10−4	8.21 × 10−3	Fmax = 0.055	0.990	2.03 × 10−5
$F=k_H\times t^{0.5}$ Higuchi c	2.065 × 10−2		0.735	9.32 × 10−3	3.00 × 10−3		0.929	1.47 × 10−4
$F=k_{KP}\times t^n$ Korsmeyer–Peppas d	4.77 × 10−2	0.32788	0.916	2.96 × 10−3	1.54 × 10−3	0.6355	0.961	8.01 × 10−5
$F=k_1\times t^m+k_2\times t^{2m}$ Peppas–Sahlin e	k1= 2.16 × 10−2 k2= −5.43 × 10−6	0.54138	0.992	2.86 × 10−4	k1 = 3.47 × 10−4 k2 = −9.54 × 10−7	1.0354	0.993	1.54 × 10−5

In all models, F is the fraction of drug released in time t. ^a k₁ = first-order release constant, ^b Fmax = maximum fraction of the drug released at infinite time, ^c k_H = Higuchi release constant, ^d k_KP = release constant incorporating structural and geometric characteristics of the drug-dosage form; n is the diffusional exponent indicating the drug-release mechanism, ^e k₁ is the constant related to the Fickian kinetics; k₂ is the constant related to Case-II relaxation kinetics; m is the diffusional exponent for a device of any geometric shape which inhibits controlled release. Plotting the fraction released (Mt/M∞) on time (min), the best fitting with the experimental data of CUR and MTR coupled was obtained by applying the Peppas–Sahlin equation, as shown in Figure 9.