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Some illustrative examples of MMR expression patterns in HNC specimens. Immunohistochemical staining (IHC), which is performed to determine the expression of MMR components such as MLH1 (A) or MSH2 (B), represents a useful tool to discriminate between MMR proficient/deficient tissues. All images are shown at 20× magnification. Images reproduced with permission from the archives of the Department of Pathology, Careggi University Hospital.
