Figure 6.

Metformin intake decreases the presence of β-catenin, c-MYC and survivin in epithelial ovarian tumours. Sequential paraffin-embedded samples from female users (M+) and non-users (M−) of metformin were used to detect oncoproteins by immunohistochemistry: β-catenin (A) c-MYC (B), or survivin (C) levels. N = 4 independent experiments (6–8 images were evaluated per experiment). Bar = 40 µm. * p < 0.05; ** p < 0.01 and *** p < 0.001 according to the Mann–Whitney test. Results are expressed as the mean ± standard error of the mean (SEM).