Table 3.
Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) of current cancer cognitive complaints and clinical, demographic and lifestyle characteristics based on 3 models: (1) chemotherapy, (2) chemotherapy + IES-R (Impact of Event Scale-Revised), (3) endocrine therapy.
| Multivariable | 1 = Chemotherapy | 2 = IES-R | 3 = Endocrine Therapy | |||
|---|---|---|---|---|---|---|
| Mean (SD) | OR | 95% CI | OR | 95% CI | OR | 95% CI |
| Chemotherapy | ||||||
| No | 1.00 | Reference | 1.00 | Reference | ||
| Yes | 2.26 | 1.67–3.05 | 2.28 | 1.68–3.08 | ||
| Post-cancer curative treatment time in years | ||||||
| ≤1 | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| 1–3 | 0.98 | 0.70–1.37 | 1.00 | 0.71–1.41 | 1.05 | 0.75–1.46 |
| ≥3 | 0.79 | 0.59–1.08 | 0.83 | 0.61–1.12 | 0.89 | 0.66–1.22 |
| Cancer without metastasis | ||||||
| Yes | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| No | 1.04 | 0.72–1.50 | 1.04 | 0.72–1.51 | 1.23 | 0.86–1.77 |
| Age in years | ||||||
| 21–44 | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| 45–64 | 0.37 | 0.28–0.51 | 0.37 | 0.27–0.50 | 0.33 | 0.24–0.44 |
| ≥65 | 0.14 | 0.07–0.27 | 0.15 | 0.07–0.30 | 0.11 | 0.05–0.21 |
| Employment | ||||||
| Full-time or part-time | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Sick leave | 1.64 | 1.08–2.49 | 1.57 | 1.03–2.52 | 1.67 | 1.11–2.52 |
| Student/retired | 0.69 | 0.45–1.04 | 0.67 | 0.44–1.03 | 0.70 | 0.46–1.05 |
| Unemployed | 1.62 | 0.93–2.84 | 1.43 | 0.81–2.52 | 1.69 | 0.97–2.94 |
| Other | 1.24 | 0.84–1.82 | 1.18 | 0.80–1.75 | 1.25 | 0.86–1.83 |
| Education level | ||||||
| Low | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Middle | 1.02 | 0.50–2.07 | 1.02 | 0.50–2.10 | 1.05 | 0.52–2.13 |
| High | 1.11 | 0.55–2.23 | 1.13 | 0.56–2.28 | 1.13 | 0.57–2.25 |
| Self-reported sleep difficulties | ||||||
| Never | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Sometimes | 1.51 | 0.91–2.49 | 1.41 | 0.85–2.33 | 1.51 | 0.92–2.49 |
| Often | 2.41 | 1.47–3.95 | 2.08 | 1.26–3.42 | 2.34 | 1.43–3.84 |
| Frequency of psychotropic treatments | ||||||
| Never | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| <1/month | 1.56 | 1.08–2.26 | 1.51 | 1.04–2.19 | 1.52 | 1.06–2.18 |
| >1/month and <1/week | 1.23 | 0.73–2.07 | 1.04 | 0.61–1.77 | 1.16 | 0.70–1.93 |
| >1/week | 1.70 | 1.23–2.36 | 1.60 | 1.15–2.23 | 1.69 | 1.23–2.34 |
| Physical activity | ||||||
| None or <once a week | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| Once a week | 0.92 | 0.66–1.30 | 0.92 | 0.65–1.29 | 0.92 | 0.66–1.30 |
| Twice a week | 1.30 | 0.95–1.76 | 1.28 | 0.94–1.74 | 1.31 | 0.96–1.77 |
| ≥3 times a week | 1.08 | 0.78–1.48 | 1.11 | 0.80–1.53 | 1.10 | 0.80–1.51 |
| Pre-existing knowledge 1 | ||||||
| Yes | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference |
| No | 1.23 | 0.96–1.56 | 1.25 | 0.98–1.59 | 1.35 | 1.07–1.71 |
| Stress symptoms (IES-R) | ||||||
| No | 1.00 | Reference | ||||
| Yes | 2.05 | 1.57–2.69 | ||||
| Endocrine therapy | ||||||
| Never | 1 | Reference | ||||
| Former | 0.96 | 0.67–1.39 | ||||
| Current | 1.11 | 0.84–1.47 | ||||
1 Pre-existing knowledge about chemotherapy-associated cognitive problems. In bold in the table: significant results.