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. 2020 Oct 16;9(10):1005. doi: 10.3390/antiox9101005

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PEG-HCCs reduce disease severity in a rat model of RA. (A) Clinical scores of paw inflammation of rats with the PIA model of RA that were treated with vehicle (n = 15) or PEG-HCCs (n = 8) every-other-day for 21 days. (B) Rheumatoid factor concentrations in the circulation of healthy rats (n = 3), rats with PIA treated with vehicle for twenty days (n = 6), and rats with PIA treated with PEG-HCCs for twenty days (n = 7). (C) In vitro invasion through Matrigel of FLS isolated from healthy rats (n = 3), vehicle-treated PIA rats (n = 3), and PEG-HCC-treated PIA rats (n = 9). * p < 0.05, *** p < 0.001. Data are presented as mean ± SEM.