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. 2020 Oct 27;12:153–172. doi: 10.2147/HMER.S264231

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© 2020 Zaccherini et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Risk of bias across all included studies (n=45 RCTs, n=10 meta-analyses), as assessed using criteria adapted from the SIGN guidelines.

Notes: Adapted from Scottish Intercollegiate Guidelines Network (SIGN). SIGN GRADING SYSTEM 1999 – 2012. Available from: (https://www.sign.ac.uk/assets/sign_grading_system_1999_2012.pdf). Creative Commons license and disclaimer available from: (http://creativecommons.org/licenses/by/4.0/legalcode).24

Abbreviation: SIGN, Scottish Intercollegiate Guidelines Network.