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. 2020 Oct 27;13:10829–10840. doi: 10.2147/OTT.S248492

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© 2020 Yuan et al.

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Exogenetic overexpression of PRIM2 recovered the inhibitory effects of DHA on proliferation and colony formation in lung cancer cells. (A) The overexpression of PRIM2 was confirmed by Western blotting assay. (B–D) The cell viability and colony formation ability of NCI-H23 cells were detected by CCK-8 assay and colony formation assay. (E–G) Measurement of cellular GSH, cellular ROS and mitochondrial MDA in NCI-H23 cells which were treated with 60 μM DHA and transfected with PRIM2 OE plasmid. (H) The protein expressions of SLC7A11 and β-catenin were analyzed by Western blotting assay. The experiments were repeated for three times. Compared with 0 μM DHA treated cells: ***p < 0.001; Compared with 60 μM DHA treated and empty vector transfected cells, ^##p < 0.01, ^###p < 0.001.