Table 1.

Definitions of toxicity outcomes.

Hospitalizations	Any Unexpected Hospitalization during nCRT
Nonhematologic toxicity 1	Any-grade mucositis, nausea, vomiting, diarrhea, constipation, anorexia, dehydration, fatigue, esophagitis, dysphagia, neurotoxicity
Hematologic toxicity 2	Neutropenia, thrombocytopenia, anemia
Grade ≥3 toxicity 3	Onset of any grade ≥3 toxicity during nCRT Hgb < 8 g/dL, ANC < 1000/mm3, Plts < 50,000/mm3, Cr < 3× baseline or >3.0 mg/dL
Dose reduction or interruption 4	Unplanned chemotherapy dose reduction or interruption

nCRT, neoadjuvant chemoradiation therapy; Hgb, hemoglobin; ANC, absolute neutrophil count; Plts, platelets; Cr, creatinine. ¹ Includes any-grade nonhematologic toxicity. ² Weighted scores given to higher grade hematologic toxicity. ³ Grade ≥3 toxicity including hematologic or renal insufficiency. ⁴ Any dose reduction or interruption regardless of percent of reduction or timing of interruption.