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Flow chart. Black fields and arrows represent HER2 positive patient selection; grey fields and arrows represent HER2 negative or unknown patient selection; HER2: human epidermal growth factor receptor 2; HR: hormone receptor; pos: positive; TNBC: triple negative breast cancer; PTZ: pertuzumab; T-DM1: trastuzumab emtansine; FU time: follow-up time.
