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KEAP1/NRF2 regulation. Under non-stressed conditions KEAP1 directs ubiquitin-mediated degradation of NRF2, resulting in minimal transcription of NRF2 targets. Under oxidative or xenobiotic stress, or when the KEAP1/NRF2 pathway is mutated, NRF2 is stabilized and promotes transcription of antioxidant response element (ARE)-containing genes.
