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Genoprotective effects of β-caryophyllene and β-caryophyllene oxide against the damage induced by condensed smoke cigarette (CSC) [161]. Both sesquiterpenes were able to counteract the DNA damage (1) and oxidative stress (2) induced by CSC, thus preventing cell mutations and the possible initiation of carcinogenesis. Moreover, β-caryophyllene was able to inhibit the activation of prosurvival STAT3 signaling (3), which is involved in chemoresistance development.
