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. 2020 Oct 18;12(10):3034. doi: 10.3390/cancers12103034

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pleiotropic and multitarget mechanisms involved in the chemopreventive properties of caryophyllane sesquiterpenes in healthy and cancer cells. The activation of CB2R is associated with the antioxidant and anti-inflammatory effects of β-caryophyllene in healthy cells. Moreover, its role in the modulation of inflammatory process and oxidative stress in cancer cells require more investigations. CB2R, CB2 receptor; TLR, Toll-killer receptor; RAGE, receptor for advanced glycation end products; GSH, glutathione; STAT3, signal transducer and activator of transcription 3; γH2AX, phosphorylated (Ser139) histone 2AX; NF-kB, nuclear factor kappa B; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; PCNA, proliferating cell nuclear antigen; CDK4, cyclin-dependent protein kinase 4; MDR1, multidrug resistance; MRP, multidrug resistance-associated protein.

Pleiotropic and multitarget mechanisms involved in the chemopreventive properties of caryophyllane sesquiterpenes in healthy and cancer cells. The activation of CB2R is associated with the antioxidant and anti-inflammatory effects of β-caryophyllene in healthy cells. Moreover, its role in the modulation of inflammatory process and oxidative stress in cancer cells require more investigations. CB2R, CB2 receptor; TLR, Toll-killer receptor; RAGE, receptor for advanced glycation end products; GSH, glutathione; STAT3, signal transducer and activator of transcription 3; γH2AX, phosphorylated (Ser139) histone 2AX; NF-kB, nuclear factor kappa B; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; mTOR, mammalian target of rapamycin; PCNA, proliferating cell nuclear antigen; CDK4, cyclin-dependent protein kinase 4; MDR1, multidrug resistance; MRP, multidrug resistance-associated protein.