Table 4.
Urinary levels of tryptophan (TRP) and its metabolites expressed in milligram per gram of creatinine and their ratios in healthy young adult individuals (group I) and in the elderly without (group II) and with mood disorders (group III) 1.
| Group | I | II | III | |||
|---|---|---|---|---|---|---|
| Gender | M | F | M | F | M | F |
| TRP | 13.4 ± 2.54 | 12.78 ± 2.18 | 12.29 ± 1.96 | 12.64 ± (2.81 | 10.26 ± 1.48 | 10.54 ± 1.04 |
| 5-HIAA | 2.68 ± 0.86 | 3.26 ± 1.12 | 2.86 ± 0.98 | 2.76 ± 0.7 | 2.37 ± 0.67 | 2.68 ± 0.59 |
| KYN | 0.43 ± 0.09 | 0.47 ± 0.09 | 0.49 ± 0.11 | 0.61 ± 0.14 * | 0.91 ± 0.25 | 0.83 ± 0.2 |
| 5-HIAA/TRP | 0.19 (0.13–0.30) | 0.29 (0.16–0.3) | 0.26 (0.19–0.3) | 0.25 (0.17–0.3) | 0.24 (0.2–0.28) | 0.27 (0.22–0.29) |
| 5-HIAA/KYN | 0.03 (0.02–0.04) | 0.03 (0.03–0.04) | 0.04 (0.03–0.04) | 0.05 (0.04–0.06) * | 0.09 (0.07–0.13) | 0.07 (0.06–0.1) |
| KynA | 2.01 ± 0.5 | 2.13 ± 0.46 | 2.36 ± 0.72 | 2.15 ± 0.61 | 2.97 ± 0.9 | 2.91 ± 0.74 |
| XA | 0.85 ± 0.23 | 0.65 ± 0.28 | 0.68 ± 0.17 | 0.9 ± 0.29 | 1.17 ± 0.20 | 0.92 ± 0.31 * |
| QA | 3.15 ± 0.79 | 3.07 ± 1.22 | 4.22 ± 0.45 | 4.18 ± 1.21 | 6.70 ± 0.64 | 7.34 ± 1.14 |
1 Mean ± SD or median and the range of I and III quartiles; 5-HIA, 5-hydroxyaminoacetic acid; KYN, L-kynurenine; KynA, kynurenic acid; XA, xanthurenic acid; QA, quinolinic acid; M, men; F, women; * p < 0.05 as compared with men.