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. 2020 Oct 30;10:18738. doi: 10.1038/s41598-020-75749-4

Table 4.

Key changes in the practice of respiratory support.

Key changes in practice 10-year incidence n (%age of available data)$ Available data n (%age) Missing data n (%age) Unadjusted odds (95% CI) Adjusted odds (95% CI)!
Total infants 948
Surfactant during initial resuscitation 855 (90.2) 948 (0.0) 0 (0.0) 0.94 (0.87, 1.01) 0.93 (0.86, 1.01)1,3,7
Surfactant at any time (absolute) 894 (94.3) 948 (0.0) 0 (0.0) 0.93 (0.84, 1.03) 0.90 (0.81, 1.00)1,3,4,*
Any non-invasive ventilation during resuscitation (face-mask, CPAP) 842 (90.6) 929 (98.0) 19 (2.0) 1.28 (1.17, 1.39)* 1.26 (1.15, 1.38)3,7,*
Any non-invasive ventilation after resuscitation 733 (81.6) 898 (94.7) 50 (5.3) 1.03 (0.97, 1.09) 1.03 (0.97, 1.10)1,2
Any mechanical ventilation during resuscitation 871 (92) 947 (99.9) 1 (0.1) 0.90 (0.82, 0.98)* 0.89 (0.81, 0.97)1,3,7,*
Any mechanical ventilation after initial resuscitation 878 (97.8) 898 (94.7) 50 (5.3) 0.80 (0.67, 0.95)* 0.80 (0.68, 0.96)1,*

Odds (95% CI) are for trend, calculated by logistic regression models with the year of birth as a continuous variable, and adjusted for gestational age at birth1, sex2, centre3 and outborn-status4, along with the interaction terms gestation*year of birth5, gestation*gender (1)6 and centre of care*outborn-status (1)7.

$All analysis was conducted after excluding missing data.

!Superscript numbers indicate significant independent variable on adjusted analysis as numbered above.