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. 2020 Oct 30;10:365. doi: 10.1038/s41398-020-01053-4

Fig. 2. Small-world topology in the patients with MDD and HCs.

Fig. 2

a Between-group comparisons showed the decreased normalized clustering coefficient (Mann–Whitney U test, U = 8427, p = 0.01, Bonferroni corrected), and small-worldness (Mann–Whitney U test, U = 8434, p = 0.01, Bonferroni corrected) in MDD patients compared to HCs. No difference was observed in normalized shortest path length (Mann–Whitney U test, U = 10,222, p = 0.98). The AUC values were adjusted by age, sex, education, and head motion. b The patients with MDD exhibited the decreased small-world topology patterns implied as a shift toward randomization in their WM functional connectomes. AUC, area under curve; HC, healthy control; MDD, major depressive disorder.