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. 2020 Oct 30;10:18703. doi: 10.1038/s41598-020-75734-x

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© Crown 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Airway BCG priming enhances both systemic and lung parenchymal CD8 T cell responses to boost vaccination. Groups of mice were immunised as per Fig. 1 and cytokine⁺ cells derived from the spleen and lung detected as described in Fig. 2. Graphs show the percentage of cytokine⁺ CD8 T cells (exhibiting any combination of IFN-γ, IL-2, TNF-α and IL-17 production) of the total CD8 T cells derived from (A) the spleen and (B) the whole lung. (C) A representative flow cytometry plot illustrating the CD45 intravascular staining. Graphs showing the (D) percentage or (E) absolute number of cytokine⁺ CD8 T cells which were resident in the lung vasculature or parenchyma. Bars represent the mean ± SEM (n = 5–11). *p < 0.05, **p < 0.01, ***p < 0.001 ****p < 0.0001, 2-way ANOVA with Tukey’s post-hoc test. Data representative of one experiment.