Table 1.
Key differentially expressed genes acquired by centrality analysis.
| Gene | logFC | adj.P.Val | MCODE | Centrality analysis by | CytoNCA | Centrality analysis by | CytoHubba | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCODE Score | Betweenness | Closeness | Degree | Eigenvector | EPC | MCC | MNC | Stress | |||
| CDK1 | 3.729327 | 3.03E−28 | 46.020339 | 6576.003525 | 0.551637 | 131 | 0.1437205 | 55.3 | 9.22E+13 | 158 | 356,658 |
| CCNB1 | 3.115417 | 1.59E−27 | 46.020339 | 3303.18478 | 0.534146 | 116 | 0.1417335 | 55.9 | 9.22E+13 | 133 | 213,424 |
| CCNA2 | 2.219921 | 2.57E−14 | 46.020339 | 2534.615585 | 0.52019 | 105 | 0.1342352 | 53.4 | 9.22E+13 | 122 | 163,390 |
| CDC20 | 2.756389 | 1.63E−14 | 46.020339 | 2758.724299 | 0.496036 | 103 | 0.1345755 | 51.8 | 9.22E+13 | 116 | 116,042 |
| MAD2L1 | 3.346366 | 4.29E−26 | 46.020339 | 1131.260005 | 0.48079 | 94 | 0.1333797 | 52.9 | 9.22E+13 | 110 | 72,556 |
| KIF11 | 3.207367 | 4.39E−28 | 46.020339 | 1464.21417 | 0.487751 | 92 | 0.1298102 | 50.4 | 9.22E+13 | 104 | 95,940 |
| CENPA | 2.75168 | 8.64E−15 | 47.094949 | 1704.200531 | 0.481319 | 92 | 0.1282006 | 50.3 | 9.22E+13 | 100 | 74,860 |
| PCNA | 2.453675 | 1.03E−37 | 43.857039 | 2862.973827 | 0.489385 | 92 | 0.1150848 | 47.9 | 9.22E+13 | 106 | 108,266 |
| EZH2 | 2.942149 | 1.48E−27 | 42.305272 | 3357.588136 | 0.511085 | 91 | 0.1046336 | 47.1 | 9.22E+13 | 112 | 243,314 |
| KIF23 | 2.687969 | 7.39E−20 | 46.020339 | 1657.240201 | 0.493799 | 89 | 0.1254939 | 49 | 9.22E+13 | 97 | 99,424 |
| TOP2A | 4.595822 | 5.72E−29 | 46.020339 | 1122.678983 | 0.493243 | 88 | 0.1293264 | 51.4 | 9.22E+13 | 104 | 94,808 |
| UBE2C | 3.062068 | 1.20E−22 | 46.020339 | 1455.353604 | 0.466951 | 88 | 0.1219277 | 48.8 | 9.22E+13 | 101 | 67,434 |
| BIRC5 | 2.792394 | 5.43E−15 | 46.020339 | 1678.399139 | 0.493799 | 88 | 0.1287475 | 48.9 | 9.22E+13 | 99 | 108,288 |
| KIF2C | 2.389307 | 1.51E−15 | 46.94026 | 1182.010234 | 0.487751 | 88 | 0.1259678 | 48 | 9.22E+13 | 97 | 85,072 |
| RRM2 | 4.481084 | 1.30E−31 | 46.020339 | 1745.829126 | 0.497727 | 86 | 0.1228496 | 50.9 | 9.22E+13 | 101 | 110,592 |
| RACGAP1 | 2.400852 | 1.87E−23 | 46.020339 | 1361.211732 | 0.493799 | 86 | 0.1225891 | 49.8 | 9.22E+13 | 94 | 93,686 |
| KIF4A | 2.206078 | 2.43E−13 | 46.94026 | 1008.406749 | 0.478689 | 80 | 0.1192849 | 46 | 9.22E+13 | 88 | 65,850 |
| KPNA2 | 3.428273 | 1.09E−42 | 46.880102 | 961.5679185 | 0.47454 | 78 | 0.111362 | 46.1 | 9.22E+13 | 86 | 91,340 |
| TYMS | 2.878076 | 1.89E−21 | 47.774118 | 1340.60442 | 0.473514 | 76 | 0.1156782 | 48.1 | 9.22E+13 | 92 | 99,082 |
| RRM1 | 2.268661 | 2.13E−25 | 40.445411 | 1145.682149 | 0.45768 | 69 | 0.0981711 | 43.2 | 9.22E+13 | 80 | 69,510 |
logFC, log2 fold change; adj.P.Val, adjusted P value; EPC, Edge Percolated Component; MCC, Maximal Clique Centrality; MNC, Maximum Neighborhood Component.