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. 2020 Oct 30;10:18711. doi: 10.1038/s41598-020-75334-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ATM is expressed within hair follicle bulbar melanocytes and correlates with pigmentation status. Overlays of ATM (green channel) and melanocyte marker GP100 (red channel) in adult human scalp showing strong and exclusive ATM expression in melanocytes within a pigmented follicle (top, 35-year old), less frequent ATM expression in a hair follicle with reduced pigmentation or mild canities (middle, 63-year old), and absent ATM expression in a grey (full canities) hair follicle (lower; 62-year old). Right panels show increased magnification (× 2) of the hair bulb melanocytes present in the central column. Yellow arrows indicate melanocytes with reduced or absent ATM expression in canities-affected scalp follicles. DAPI nuclear stain is shown in blue channel. Scale bar is shown on each image. Brightfield images of follicle pigmentation are shown in the inset image (follicle outline is indicated with black dashed line in 62-year old with full canities). Donor age is indicated on the right.