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. 2020 Oct 19;9(10):1494. doi: 10.3390/foods9101494

Figure 4.

Figure 4

NV-LJ3402 enhances mitochondrial levels and increases the body temperature in HFD-fed mice. (a,b) Mitochondrial DNA (mtDNA) copy number (a) and citrate synthase activity (b) in inguinal WAT (iWAT) and eWAT of HFD and HFD-NV-LJ3402 mice (n = 5–7 per group). (c) Day 6 3T3-L1 adipocytes were treated with NV-LJ3402-CM for 48 h, and then mtDNA copy number and citrate synthase activity were measured on day 8, as indicated. mtDNA levels were normalized to those of nuclear genomic DNA. The results are from three independent experiments. (d) Core body temperature was measured based on rectal temperatures at 25 °C (0 h) and 4 °C for different durations (2‒6 h) (n = 7 per group). All data are expressed as the mean ± S.E.M. HFD vs. HFD+NV-LJ3402, con vs. NV-LJ3402-CM, * p < 0.05.