Table 3.
Clinical Results Obtained in Patients Refractory to First-Line CT
| Author | N | Disease at HDC | OS | PFS | TRM | Stem cells |
|---|---|---|---|---|---|---|
| Andre,80 1999 | 86 | CT S 62% | 35% @ 5 y CR= 60% PD= 20% |
25% @ 5 y | 8% | BM |
| Sweetenham,81 1999 | 175 | NS | 36% @ 5 y | 32% @ 5 y | 14% | BM |
| Josting,82 2000 | 206 | CT S 43% | 43% @ 5 y 0= 55% 3= 0% |
31% @ 5 y | 10% | BM + PBSC |
| Constans,83 2003 | 62 | NS | 26% @ 5 y | 15% @ 5 y | 14% | BM + PBSC |
| Czyz,84 2004 | 76 | NS | 33% @ 5 y | NS | 9% | BM + PBSC |
Notes: In Josting et al risk factors were: PS <90%, age >50 y, and chemosensitive disease (CT S) to first-line CT.
Abbreviations: NS, not stated; BM, bone marrow; PBSC, peripheral blood stem cell.