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αvβ8-Integrin affinities (expressed as 50% inhibition concentrations, IC50) and n-octanol-PBS distribution coefficients (log D7.4). Affinities were determined using the non-radioactive 69/71GaIII complexes, where applicable
| Compound | IC50 (95% confidence interval) [nm] | log D7.4 |
|---|---|---|
| 68Ga-Triveoctin (trimer) | 5.7 (3.6–9.0) | − 3.1 ± 0.1 |
| 68Ga-TRAP-AvB8 (monomer) | 38 (25–58) | − 3.9 ± 0.1 |
| AvB8-pentynoic amide | 17 (12–24) | n/a |
