Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 11;94(11):3799–3817. doi: 10.1007/s00204-020-02900-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — MeHg transport across MDCKII-parental and MDCKII-MRP1 cells over 4 h. a Predominant transport of MeHg in the apical-to-basolateral (A–B) direction in MDCKII-MRP1 cells. b MRP1 inhibitor MK-571 (50 µM) decreased A–B MeHg transport in MDCKII-MRP1 cells. c MDCKII-parental cells show reduced A–B MeHg transport than MDCKII-MRP1 cells. d Values of permeable coefficient (Papp) were calculated at 120 min within linear phase of MeHg transport. Statistical significance between efflux ratios (ER = Papp_A-B/Papp_B-A) of MeHg transport in MDCKII-MRP1 (ER = 9.51), MDCKII-MRP1 + MK-571 (ER = 2.87) and MDCKII-parental cells (ER = 3.86) revealed MeHg as MRP1 substrate. e Retention of MeHg in cell monolayer after transport assay. Data are presented as means ± SD (n ≥ 3). Statistical significance was evaluated by parametric student’s t-test (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001)