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. 2020 Sep 3;94(11):3759–3774. doi: 10.1007/s00204-020-02853-9

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© The Author(s) 2020

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Fig. 6 — Tentative structures of retrorsine metabolites after incubation with human and rat liver microsomes. In some cases, biotransformation could only be assigned to distinct regions of the molecule (encircled in red). The metabolites were summarized into two groups: red box—dehydrogenation group (the insertion of an additional double bond); black box—oxygenation reactions (color figure online)