Table 1.
Baseline characteristics of critically ill children with haematological malignancies
| All patients (n = 37) |
Standard-dose group (>0.1 mg/kg/day) (n = 22) |
Low-dose group (≤0.1 mg/kg/day) (n = 15) |
P value | |
|---|---|---|---|---|
| Age | 6.4 ± 3.4 | 5.1 ± 3.1 | 8.3 ± 2.8 | 0.002* |
| Sex | ||||
| Male | 28 | 16 | 12 | 0.908 |
| Female | 9 | 6 | 3 | |
| Weight | 22.3 ± 10.9 | 17.8 ± 8.3 | 28.9 ± 11.0 | 0.001* |
| Disease course | 35 ± 26 | 35 ± 27 | 35 ± 25 | 0.999 |
| Rasburicase exposure | ||||
| Total dose (mg/kg) | 0.58 ± 0.42 | 0.76 ± 0.41 | 0.33 ± 0.29 | 0.001* |
| Daily dose (mg/kg/day) | 0.13 ± 0.06 | 0.16 ± 0.04 | 0.08 ± 0.02 | <0.001* |
| Frequency (times) | 4.58 ± 2.97 | 4.89 ± 2.98 | 4.13 ± 3.00 | 0.456 |
| Tumour histology | ||||
| Burkitt’s lymphoma | 30 | 19 | 11 | 0.405 |
| Lymphoblastic lymphoma | 2 | 1 | 1 | |
| Acute lymphoblastic Leukaemia | 4 | 1 | 3 | |
| Acute myeloid Leukaemia | 1 | 1 | 0 | |
| Laboratory values at admission | ||||
| BUN (mmol/L) | 4.68 ± 2.38 | 4.89 ± 2.74 | 4.38 ± 1.77 | 0.529 |
| SCr (μmol/L) | 55 ± 29 | 55 ± 33 | 55 ± 23 | 0.976 |
| UA (μmol/L) | 677 ± 288 | 625 ± 291 | 754 ± 274 | 0.184 |
| LDH (U/L) | 2179 (1137,3282) | 1871 (1056,2768) | 2805 (1265,4586) | 0.234 |
BUN Blood urea nitrogen, SCr serum creatinine, UA uric acid, LDH lactate dehydrogenase; *P < 0.05