TABLE 2.

Pooled ALT Means and Estimated Upper Thresholds, by Metabolic Subgroups

Population	Number of Studies	Number of Participants	Pooled ALT Mean (U/L) †	95% CI	ALT Upper Threshold (95th Percentile) (U/L)
Normal weight	11	183,068	16	14‐19	28
Sensitivity analysis
Only studies with reported mean ALT*	9	175,930	18	15‐20	30
Only studies with low risk of bias	11	183,068	17	15‐ 19	29
Overweight/obese	9	10,653	25	20‐29	39
Sensitivity analysis
Only studies with reported mean ALT*	8	7,415	25	20‐30	40
Only studies with low risk of bias included	8	10,581	21	17‐26	33
No DM	4	26,274	19	17‐22	33
Sensitivity analysis
Only studies with low risk of bias	4	26,274	19	17‐22	34
DM	12	9,245	22	20‐25	36
Sensitivity analysis
Only studies with reported mean ALT*	8	4,011	25	21‐29	39
Only studies with low risk of bias	5	4,371	24	20‐28	44

^*Studies with ALT converted from median were not included.

^†All I ² > 98.0% and all P values for I ² < 0.05.