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Potential mechanism of QSG efficacy on HF rats. QSG improved heart function and decreased cardiac remodeling by regulating the calcium signaling pathway. QSG ameliorated cytoplasmic Ca2+ overload in the cardiac cells, manifested by downregulation of CaV1.2 and upregulation of the SERCA2a and further confirmed by inhibition of CaMKII and CaN after QSG treatment.
