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. 2020 Oct 20;2020:3645371. doi: 10.1155/2020/3645371

Figure 5.

Figure 5

Effect of E2F1 on trophoblast cell proliferation. (a, b) The expression of E2F1 was upregulated by pcDNA.1-E2F1, and the inhibited E2F1 by miR-136 overexpression was abolished by pcDNA3.1-E2F1 in both HRT-8/SVneo and BeWo cells (∗∗∗P < 0.001 vs. HG; ###P < 0.001 vs. miR-136 mimic). (c, d) The inhibited trophoblast cell proliferation induced by the miR-136 overexpression was reversed by the upregulation of E2F1 in both HRT-8/SVneo and BeWo cells (∗∗∗P < 0.001 vs. HG; ###P < 0.001 vs. miR-136 mimic). HG: high glucose.