Table 7.
Association of TGFBR3 CGG haplotype with laboratory biomarkers.
| Parameter | TGFBR3 CGG haplotype | P value | |
|---|---|---|---|
| CGG N = 63 |
Non-CGG N = 112 |
||
| Median (IQR) | Median (IQR) | ||
| Hemoglobin pattern | |||
| Fetal hemoglobin, % | 4.50 (1.70–8.15) | 5.85 (1.52–11.70) | 0.331 |
| S hemoglobin, % | 80.70 (52.00–90.53) | 79.70 (55.35–88.20) | 0.676 |
| Hematological markers | |||
| RBC, 106/mL | 2.98 (2.54–3.99) | 2.95 (2.53–3.78) | 0.681 |
| Hemoglobin, g/dL | 9.00 (7.85–11.35) | 9.15 (8.10–10.80) | 0.958 |
| Hematocrit, % | 27.00 (23.70–33.50) | 27.40 (23.58–32.10) | 0.977 |
| MCV, fL | 86.20 (80.05–93.78) | 89.75 (80.73–97.03) | 0.230 |
| MCH, ρg | 29.35 (27.13–32.38) | 30.25 (27.40–32.68) | 0.242∗ |
| MCHC, g/dL | 33.90 (33.20–34.45) | 33.70 (33.20–34.28) | 0.304∗ |
| RDW, % | 21.60 (18.10–24.50) | 20.40 (17.70–23.70) | 0.177 |
| Reticulocyte count, /mL | 131100 (106860–170440) | 139385 (91350–180125) | 0.948 |
| WBC, /mL | 10800 (9150–13000) | 10300 (7800–13400) | 0.152∗ |
| Neutrophils, /mL | 4876 (3750–6650) | 4810 (3392–6600) | 0.452 |
| Eosinophils, /mL | 300.00 (182.00–520.00) | 335.00 (146.50–552.50) | 0.969 |
| Lymphocytes, /mL | 3840 (2943–4640) | 3500 (2574–4440) | 0.090 |
| Monocytes, /mL | 944.00 (597.00–1346.00) | 840.50 (575.30–1253.00) | 0.209 |
| Platelet count, x103/mL | 389.00 (310.50–484.50) | 371.50 (267.30–454.80) | 0.171∗ |
| Platelet volume average, fL | 7.90 (7.50–8.50) | 8.00 (7.30–8.60) | 0.989∗ |
| Plateletcrit, % | 0.32 (0.24–0.40) | 0.28 (0.21–0.35) | 0.046 |
| Biochemical markers | |||
| TC, mg/dL | 128.00 (112.00–147.00) | 119.00 (103.50–138.30) | 0.029 |
| HDL-C, mg/dL | 36.00 (31.75–42.00) | 36.00 (32.00–43.00) | 0.645∗ |
| LDL-C, mg/dL | 68.40 (55.40–82.80) | 58.50 (48.40–78.00) | 0.035 |
| VLDL-C, mg/dL | 20.80 (15.45–26.40) | 19.10 (14.45–23.50) | 0.176 |
| Triglycerides, mg/dL | 105.00 (77.50–132.50) | 94.00 (72.50–117.00) | 0.141 |
| Non-HDL-C, mg/dL | 91.00 (76.00–108.00) | 79.00 (68.00–101.50) | 0.030 |
| TC/HDL-C ratio | 3.36 (2.86–4.32) | 3.22 (2.67–3.96) | 0.134 |
| Triglycerides/HDL-C ratio | 2.89 (1.87–3.96) | 2.51 (1.82–3.45) | 0.086 |
| LDL-C/HDL-C ratio | 1.83 (1.41–2.43) | 1.68 (1.20–2.20) | 0.135 |
| Total bilirubin, mg/dL | 2.08 (1.26–3.14) | 1.92 (1.25–3.20) | 0.657 |
| Direct bilirubin, mg/dL | 0.34 (0.23–0.45) | 0.36 (0.26–0.49) | 0.373 |
| Indirect bilirubin, mg/dL | 1.60 (0.96–2.66) | 1.47 (0.88–2.79) | 0.664 |
| LDH, U/L | 886.00 (651.00–1261.00) | 855.00 (614.50–1224.00) | 0.558 |
| ALT, U/L | 15.00 (11.00–18.00) | 14.00 (10.00–20.00) | 0.675 |
| AST, U/L | 36.50 (26.00–49.50) | 38.00 (24.00–54.00) | 0.855 |
| Total protein, g/dL | 8.33 (8.02–8.89) | 8.09 (7.66–8.82) | 0.055∗ |
| Albumin, g/dL | 4.77 (4.60–5.05) | 4.79 (4.59–4.98) | 0.625∗ |
| Globulin, g/dL | 3.60 (3.28–4.03) | 3.32 (3.00–3.93) | 0.022 |
| Albumin/globulin ratio | 1.31 (1.20–1.50) | 1.40 (1.26–1.61) | 0.059∗ |
| Iron, mcg/dL | 88.00 (74.25–105.00) | 92.00 (67.50–127.50) | 0.363 |
| Ferritin, ηg/mL | 142.00 (98.30–219.20) | 155.70 (73.25–254.30) | 0.931 |
| Urea nitrogen, mg/dL | 17.00 (14.70–20.49) | 17.10 (14.00–21.89) | 0.915 |
| Creatinine, mg/dL | 0.48 (0.38–0.59) | 0.49 (0.38–0.61) | 0.605 |
| CRP, mg/L | 2.43 (1.59–3.78) | 2.37 (1.80–3.53) | 0.780 |
| AAT, mg/dL | 65.80 (34.75–121.00) | 72.55 (39.20–116.00) | 0.566 |
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very-low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at P < 0.05. All P values obtained by the Mann–Whitney U test, except for those with asterisk (∗), for which the independent t-test was used.