Table 7.
Antioxidant enzyme activities of 100-400 mg/kg/day of IGESE in DOX-treated rat cardiac tissue.
| Groups | Antioxidant parameters | |||||
|---|---|---|---|---|---|---|
| GSH | GST | GPx | SOD | CAT | MDA | |
| I | 18.8 ± 1.6 | 1.6 ± 0.2 | 1.2 ± 0.1 | 9.5 ± 1.8 | 43.6 ± 4.7 | 4.3 ± 0.5 |
| II | 20.4 ± 0.6 | 2.7 ± 0.2b+ | 2.0 ± 0.2 | 10.4 ± 1.2 | 62.7 ± 4.4 | 6.0 ± 0.5 |
| III | 14.8 ± 0.8b− | 1.1 ± 0.2a− | 1.0 ± 0.1a− | 6.9 ± 0.6b− | 16.7 ± 2.3c− | 12.8 ± 1.0c+ |
| IV | 21.3 ± 1.3e+,e | 2.6 ± 0.3e+,e | 2.4 ± 0.2e+,e | 11.5 ± 1.5e+,e | 51.4 ± 5.2d+,d | 5.2 ± 0.5e− |
| V | 17.0 ± 1.4d | 2.0 ± 0.2d | 1.3 ± 0.1 | 11.1 ± 1.5d+,d | 54.2 ± 6.5d+,d | 5.3 ± 0.6e− |
| VI | 19.6 ± 1.8d+,d | 2.4 ± 0.1e+,e | 2.3 ± 0.3e+,e | 12.8 ± 1.4e+,e | 56.6 ± 4.3d+,d | 3.9 ± 0.4f− |
| VII | 24.7 ± 1.3e+,e | 3.0 ± 0.4f+,f | 3.3 ± 0.4f+,f | 15.4 ± 1.6e+,e | 78.7 ± 6.9f+,f | 3.5 ± 0.4f− |
b+ represents a significant increase at p < 0.001 when compared to untreated negative (normal) control (Group I) values; c+ represents a significant increase at p < 0.0001 when compared to IGESE-only treated (Group II) values; a-,b-, andc- represent significant decreases at p < 0.05, p < 0.001, and p < 0.0001, respectively, when compared to Groups I values; d+ and e+ represent significant increases at p < 0.001 and p < 0.0001, respectively, when compared to untreated positive control (DOX-only treated, Group III) values; while e- and f- represent significant decreases at p < 0.001 and p < 0.0001, respectively, when compared to untreated positive control (DOX-treated only, Group III) values, respectively. d, e, and f represent significant increases at p < 0.05, p < 0.001, and p < 0.0001, respectively, when compared to untreated positive control (DOX-treated only, Group III).