Figure 1.

Schematic of Notch receptors and ligand families. The Notch signaling pathway includes four Notch receptors (Notch1, 2, 3 and 4) and five canonical ligands (Jagged 1 and 2, Delta-like 1 and 4, and Delta-like 3). Notch receptors comprise extracellular domains, transmembrane domains, and intracellular domains. The ligands of Notch receptors can be divided into two groups according to the length and subtype of the EGF-like repeats. RAM: Rbpj interacting domain; ANK: ankyrin repeat; NLS: nuclear localization signal; TAD: transcriptional activator domain; PEST domain: proline-, glutamine-, serine-, and threonine-rich domain; DSL: Delta-Serrate-Lag2; CR: cysteine-rich region.