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. 2020 Oct 22;2020:1809408. doi: 10.1155/2020/1809408

Figure 2.

Figure 2

Schematic of Notch signaling. Notch receptor occupation by ligands promotes proteolytic changes via γ-secretase and ADAM. Proteolytic cleavage of the receptor releases the NICD. The NICD targets the nucleus and promotes transcription by binding to the CSL transcription factor in the recipient cell. Endocytosis of the ligand/NECD complex can contribute to the Notch activation via dissociation of the NECD from the Notch heterodimer. NECD: Notch extracellular domain; NICD: Notch intracellular domain; CSL: CBF-1, suppressor of hairless, Lag; ADAM: a disintegrin and metalloprotease.