Table 1.

Notch3 and renal diseases.

Notch3 source	Diseases
VSMCs	CADASIL
Podocytes	FSGS, lupus nephritis, RPGN
PECs	FSGS, lupus nephritis, RPGN
Mesangial cells	IgA nephropathy, membranoproliferative glomerulonephritis, or metabolic diseases (such as diabetes)
Renal epithelial cells	AKI, obstructive nephropathy
Cyst-lining epithelial cells	PKD

VSMCs: vascular smooth muscle cells; CADASIL: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; FSGS: focal segmental glomerulosclerosis; RPGN: rapidly progressive glomerulonephritis; AKI: acute kidney injury; PKD: polycystic kidney disease.