Figure 6.

Pearson's correlation between CDKN1a and NRF2. Cell cycle arrest thus increase in CDKN1a positively correlates with NRF2 expression (p < 0.01) (a). Not all secondary plant ingredients are NRF2 activators. Relative quantification values of NRF2 comparing all treatments regarding BrdU control (b+c). Anthocyanidin 50 μM, resveratrol 15 μM, and both roxithromycin concentrations increased NRF2 antioxidative defense pathway significantly (b). EGCG, resveratrol, spermidine mix 30 μM, both phloretin concentrations, but also endogenous substances, like spermidine and butyrate diminished NRF2 assuming lower ROS (b+c). Statistical significance was defined ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.005; ^∗∗∗∗p < 0.001. The results were expressed as mean ± SD. Statistical significance between compounds and concentrations to the control was determined by one-way ANOVA with Dunnett's post hoc test.