Table 1.

DNA methylation in DPSCs.

Epigenetic modifier	Epigenetic mark	Results
TET1	DNA demethylation	TET1, existing both in the cytoplasm and nuclei of the DPSCs, can improve the proliferation and odontogenic differentiation [102–104].
5-Aza-CdR	DNMT inhibitor	The inhibition of DNA methylation by 5-Aza negatively regulates the proliferation and enhances the myogenic and odontogenic differentiation [98, 100, 101].
RG108	DNMT inhibitor	SP1 can improve the expression of KLF4 through binding to the demethylated promoter region during the odontoblastic differentiation [99].