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. 2020 Oct 13;2020:8876265. doi: 10.1155/2020/8876265

Table 2.

Histone modifications in DPSCs.

Epigenetic modifiers Epigenetic marks Targets Differentiation
Histone methylation
 EZH2 H3K27me3 Wnt/β-catenin pathway Inflammation, proliferation, osteogenic [110, 111]
 EHMT1 H3K9me2 RUNX2 Osteogenic [113]
 MLL H3K4me3 Wnt5a Odontogenic [119]
Histone demethylation
 KDM5A H3K4me3 DMP1, DSPP, OSX, and OCN Odontogenic [121]
 KDM6B H3K27me3 Wnt5a, BMP2 Osteo/odontogenic [116, 117, 119]
Histone acetylation
 HAT H3 acetylation DSPP Odontogenic [125]
 p300 H3K9ac NANOG, SOX2, DSPP, OCN, Dmp1, and Sp7 Pluripotency, proliferation, odontogenic [126, 127, 132, 134]
Histone deacetylation
 HDAC3 H3K27ac Dmp1, Sp7 Odontogenic [132, 134]
 HDAC6 Odontogenic [131]