Table 2.
Histone modifications in DPSCs.
Epigenetic modifiers | Epigenetic marks | Targets | Differentiation |
---|---|---|---|
Histone methylation | |||
EZH2 | H3K27me3 | Wnt/β-catenin pathway | Inflammation, proliferation, osteogenic [110, 111] |
EHMT1 | H3K9me2 | RUNX2 | Osteogenic [113] |
MLL | H3K4me3 | Wnt5a | Odontogenic [119] |
Histone demethylation | |||
KDM5A | H3K4me3 | DMP1, DSPP, OSX, and OCN | Odontogenic [121] |
KDM6B | H3K27me3 | Wnt5a, BMP2 | Osteo/odontogenic [116, 117, 119] |
Histone acetylation | |||
HAT | H3 acetylation | DSPP | Odontogenic [125] |
p300 | H3K9ac | NANOG, SOX2, DSPP, OCN, Dmp1, and Sp7 | Pluripotency, proliferation, odontogenic [126, 127, 132, 134] |
Histone deacetylation | |||
HDAC3 | H3K27ac | Dmp1, Sp7 | Odontogenic [132, 134] |
HDAC6 | Odontogenic [131] |