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. 2020 Oct 31;20:528. doi: 10.1186/s12935-020-01618-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Silencing of PRC1 arrested more cells in G2/M phase and induces cell apoptosis in HCT116 and SW480 cells. a Cell cycle distribution of HCT116 and SW480 cells in the three groups (shControl, shPRC1-1, and shPRC1-2). b Percentage of cells in cell cycle phase G0/GA, S, and G2/M. c The expression levels of cell cycle related proteins (Cdc25c, Cdc2, Cyclin B1, P21, and P27) were detected by western blotting. d Cell apoptosis in HCT116 and SW480 cells detected by flow cytometry. e Apoptosis rate in HCT116 and SW480 cells in the three groups. f The expression level apoptosis related proteins (pro caspase 3, cleaved caspase 3, full length PARP, Bcl2, Bcl-xl, and Bax) was detected by western blotting. Data were expressed as the mean ± standard deviation (mean ± SD). *P < 0.05, **P < 0.01, # P < 0.001