Table 2.
Factors for microvascular invasion on univariate and multivariate analyses
| Variables | OR | Univariate Analysis | OR | Multivariate Analysis | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |||
| Age | 1.009 | 0.981 ~ 1.038 | 0.545 | NA | NA | |
| Sex, male versus female | 0.734 | 0.232 ~ 2.317 | 0.598 | NA | NA | |
| HBsAg, positive versus negative | 1.173 | 0.469 ~ 2.930 | 0.733 | NA | NA | |
| Liver cirrhosis, yes versus no | 1.738 | 0.747 ~ 4.044 | 0.200 | NA | NA | |
| Child-Pugh score, B versus A | 1.389 | 0.333 ~ 5.800 | 0.652 | NA | NA | |
| ALT | 1.016 | 0.993 ~ 1.039 | 0.169 | NA | NA | |
| AFP (ng/ml) ≤ 400 versus > 400 | 14.571 | 5.718 ~ 37.135 | < 0.001 | 6.702 | 2.149 ~ 33.354 | 0.002 |
| ICG-R15 (%) | 0.988 | 0.907 ~ 1.076 | 0.781 | NA | NA | |
| Tumor size | 1.170 | 1.063 ~ 1.288 | 0.001 | 1.213 | 1.031 ~ 1.427 | 0.020 |
| No. of tumors, multiple versus single | 6.286 | 2.456 ~ 16.090 | < 0.001 | 2.059 | 0.470 ~ 9.010 | 0.338 |
| Tumor encapsulation, yes versus no | 0.773 | 0.383 ~ 1.562 | 0.473 | NA | NA | |
| Edmondson stage, III-IV versus I-II | 1.133 | 0.572 ~ 2.244 | 0.032 | 1.484 | 0.571 ~ 4.259 | 0.463 |
| Ki67 (%) | 1.027 | 1.011 ~ 1.044 | 0.003 | 0.994 | 0.968 ~ 1.021 | 0.664 |
| PVTT, yes versus no | 7.435 | 2.771 ~ 19.950 | < 0.001 | 2.413 | 0.351 ~ 16.590 | 0.370 |
| Satellite lesion, yes versus no | 8.437 | 2.673 ~ 26.630 | < 0.001 | 2.169 | 0.340 ~ 13.826 | 0.413 |
| BCLC stage, 0 + A versus B + C | 3.984 | 1.941 ~ 8.177 | < 0.001 | 0.683 | 0.163 ~ 2.866 | 0.602 |
| Preoperative CTC5ml | 1.935 | 1.500 ~ 2.488 | < 0.001 | 1.757 | 1.344 ~ 2.295 | < 0.001 |
ALT alanine transaminase, AFP alpha fetoprotein, HBsAg hepatitis B surface antigen, ICG R15 min (%) indocyanine green 15 min retention rate, PVTT portal vein tumor thrombosis, BCLC Barcelona Clinic Liver Cancer staging system, CTC circulating tumor cell