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. 2020 Oct 31;21:287. doi: 10.1186/s12931-020-01518-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Overexpression of CXCR7 promotes growth of lung cancer cells and metastases in SCID/Beige mice. Mice were injected intravenously with lung cancer cells of A549-GFPL or A549-GFPL -CXCR7-O cells via tail vein injection. a. Continuous images are presented from firefly luciferase bioluminescence imaging for tumors every week until 5 weeks (From top to bottom). Scale bar depicts range of photon flux values as pseudocolor display with red and blue representing high and low values, respectively. b. Quantified data for photon flux from each group of mice. Graph displays mean values + SEM. ***, p < 0.001. c. Lung tissues from A549-GFPL (left) and A549-GFPL-CXCR7-O (right) cell-derived tumors were subjected to immunohistochemical staining for CXCR7.Nuclei were counterstained with hematoxylin (blue) (Magnification:200×). d. GFP fluorescence image. DAPI was used for nuclear detection (Magnification:200×)