Table 1.
Allocation of pigs to the 4 experimental groups
| Parameter | Total | Sham + Veh | Sham + TPPU | CA + Veh | CA + TPPU |
|---|---|---|---|---|---|
| Intent-to-treat | 46 | 11 | 10 | 13 | 12 |
| Did not complete 4 day protocol | 12 | 3 | 1 | 4 | 4 |
| Survived 4 day protocol | 34 | 8 | 9 | 9 | 8 |
| Reasons for death | |||||
| Could not be resuscitated | 4 | N/A | N/A | 2 | 2 |
| Could not be extubated | 3 | 2 | 0 | 0 | 1 |
| Poor perfusion after extubation | 1 | 0 | 0 | 0 | 1 |
| Refractory seizures | 1 | 0 | 0 | 1 | 0 |
| Severe hypotension prior to protocol initiation | 2 | 1 | 0 | 1 | 0 |
| Other | 1 | 0 | 1a | 0 | 0 |
| Asphyxia duration in 4 d survivors | |||||
| 7 min | 15 | N/A | N/A | 8 | 7 |
| 8 min | 2 | N/A | N/A | 1 | 1 |
| Received ≥ 1 dose of vehicle/drug prior to death | 6 | 2 | 1 | 1 | 2 |
CA, cardiac arrest; N/A, not applicable; Veh, vehicle
aDied suddenly after 2nd TPPU injection, likely secondary to venous air embolism