Fig. 3.

Levels of sAPPα and sAPPβ in CSF samples. Western blots of CSF samples from two controls (C), p.Tyr167* mutation carriers (mAD; cases I.1 and I.3), and sporadic AD (sAD) blotted with specific sAPPα (a) and sAPPβ (b) antibodies. Densitometric quantification of the 110- and 120-kDa sAPPα (a) and sAPPβ (b) bands for controls (n = 12; black circles) and AD cases (sAD, n = 10; white circles; mAD, n = 2; gray triangles). c Graphs of the sAPPα/sAPPβ ratios (for the 110- and 120-kDa species) for each sample. All data represent the means ± SEM in arbitrary units. For AD, means ± SEM represent values for sAD