Table 2.
Stratification analysis of the meta-analysis for overall survival in patients with gastrointestinal malignancy
| Subgroup | No. study | No. patients | Pooled HR (95% CI) | p | p for subgroup difference | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2(%) | PQ | ||||||
| Altogether | 8 | 1805 | 1.94(1.65–2.28) | < 0.001 | 0.0 | 0.851 | |
| Publishing time | 0.753 | ||||||
| < 2019 | 2 | 353 | 2.04(1.44–2.88) | < 0.001 | 0.0 | 0.898 | |
| ≥ 2019 | 6 | 1452 | 1.91(1.59–2.30) | < 0.001 | 0.0 | 0.665 | |
| Country | 0.351 | ||||||
| China | 2 | 512 | 1.79(1.41–2.26) | < 0.001 | 0.0 | 0.836 | |
| Japan | 6 | 1293 | 2.09(1.66–2.62) | < 0.001 | 0.0 | 0.787 | |
| Sample | 0.175 | ||||||
| < 300 | 5 | 1295 | 1.84(1.53–2.20) | < 0.001 | 0.0 | 0.967 | |
| ≥ 300 | 3 | 510 | 2.46(1.68–3.61) | < 0.001 | 0.0 | 0.623 | |
| Cutoff value | 0.873 | ||||||
| < 98 | 3 | 763 | 1.90(1.42–2.54) | < 0.001 | 0.0 | 0.831 | |
| ≥ 98 | 5 | 1042 | 1.96(1.60–2.38) | < 0.001 | 0.0 | 0.567 | |
| Cancer site | 0.673 | ||||||
| ESCC | 3 | 597 | 1.91(1.44–2.53) | < 0.001 | 0.0 | 0.821 | |
| GC | 1 | 303 | 2.09(1.11–3.96) | 0.023 | — | — | |
| PDAC | 1 | 282 | 1.76(1.32–2.34) | < 0.001 | — | — | |
| CRLM | 1 | 80 | 3.72(1.41–9.85) | 0.008 | — | — | |
| CRC | 2 | 543 | 2.04(1.47–2.83) | < 0.001 | 0.0 | 0.437 | |
| Primary therapy | 0.181 | ||||||
| With-surgery | 7 | 1725 | 1.90(1.61–2.24) | < 0.001 | 0.0 | 0.956 | |
| Mixed | 1 | 80 | 3.72(1.41–9.85) | ||||