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DNA damage studies on intact spheroids were performed using steps similar to those in the CometChip experiments. (A) Proposed method for SpheroidChip analysis compared to CometChip analysis. (B) Geometry of microwell pattern used for comet analysis. Microwell spacing creates room for comet tails. (C) Comet analysis in CometChip versus SpheroidChip analysis. (D) Examples of H2O2 treated spheroid-comets.
